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Semax

$43.69

Semax is a high-purity synthetic heptapeptide, an analogue of adrenocorticotropic hormone (ACTH) fragment 4-10, designed exclusively for laboratory research. With the sequence Met-Glu-His-Phe-Pro-Gly-Pro, Semax is utilized to investigate neuroprotective, nootropic, and stress-regulatory mechanisms. Supplied as a lyophilized powder for reconstitution, Semax provides researchers with a precise tool to study its effects on cognitive function, neuroprotection, and metabolic regulation in experimental models.

Category: Peptides

Description
Additional information

Description

What is Semax?

Semax Structure

Molecular Formula

C₃₇H₅₁N₉O₁₀S

Synonyms

DTXSID601001439
Q4415058
L-Methionyl-L-alpha-glutamylhistidyl-L-phenylalanyl-L-prolylglycyl-L-proline
(2S)-1-[2-([(2S)-1-[(2S)-2-([2-([(2S)-2-([(2S)-2-amino-4-methylsulfanylbutanoyl]amino)-5-hydroxy-5-oxopentanoyl]amino)-3-(1H-imidazol-5-yl)propanoyl]amino)-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino)acetyl]pyrrolidine-2-carboxylic acid

Research Applications:

Semax is extensively studied in preclinical research for its potential to enhance cognitive performance, reduce stress-induced metabolic disturbances, and support tissue repair in cellular and animal models. Investigations focus on its ability to modulate brain-derived neurotrophic factor (BDNF) and serotonin levels, which may mitigate stress-related overeating, supporting weight management studies. Research also explores its neuroprotective and anti-inflammatory effects, which could aid muscle recovery by reducing oxidative stress and inflammation associated with exercise or injury. Its role in improving mitochondrial function and metabolic health makes Semax a key compound for research into overall health, stress resilience, and recovery processes.

Research Links:

Dolotov, O. V., et al. (2006). “Semax, an analogue of ACTH(4-10), induces the expression of brain-derived neurotrophic factor in rat brain.” Neuroscience Letters, 403(1-2), 170-175. https://pubmed.ncbi.nlm.nih.gov/16750888/
- Investigates Semax’s role in BDNF expression, relevant to stress reduction and metabolic health.
Shadrina, M. I., et al. (2001). “Neuroprotective effects of Semax in a model of ischemic brain injury in rats.” Bulletin of Experimental Biology and Medicine, 131(6), 533-536. https://pubmed.ncbi.nlm.nih.gov/11586391/
- Examines Semax’s neuroprotective effects, with implications for muscle recovery and health.
Levitskaya, N. G., et al. (2004). “Semax prevents stress-induced behavioral changes and modulates immune responses in rats.” Journal of Neuroimmunology, 149(1-2), 182-189. https://pubmed.ncbi.nlm.nih.gov/15020077/
- Studies Semax’s effects on stress and immune function, supporting weight management research.
Myasoedov, N. F., et al. (1999). “The influence of Semax on the antioxidant status of brain tissue under stress conditions.” Neuroscience and Behavioral Physiology, 29(4), 419-423. https://pubmed.ncbi.nlm.nih.gov/10582222/
- Explores Semax’s antioxidant effects, relevant to muscle recovery and oxidative stress reduction.
Storozhevykh, T. P., et al. (2007). “Semax enhances mitochondrial function and protects neurons in vitro.” Mitochondrion, 7(4), 283-288. https://pubmed.ncbi.nlm.nih.gov/17409004/
- Investigates Semax’s effects on mitochondrial function, supporting metabolic and recovery research.

Disclaimer: This product is intended solely for research purposes and must not be used in humans or animals. Purchaser assumes full responsibility for safe and compliant use.

Additional information

CAS	80714-61-0
PubChem CID	122178
Molecular Weight	813.92 g/mol
Amino Acid Sequence	Met-Glu-His-Phe-Pro-Gly-Pro
PubChem Link	https://pubchem.ncbi.nlm.nih.gov/compound/122178
Product Note	For laboratory use only. Not for human or veterinary use. Proper handling and storage (-20°C) are required to maintain stability. Ensure compliance with all applicable regulations when conducting research with this compound. Peptides will arrive in a lyophilized (powder) form for maximum stability.